849774-19-2Relevant articles and documents
Catalytic asymmetric synthesis of α-(trifluoromethyl)benzylamine via cinchonidine derived base-catalyzed biomimetic 1,3-proton shift reaction
Soloshonok, Vadim A.,Yasumoto, Manabu
, p. 170 - 173 (2007)
Here we describe catalytic asymmetric synthesis of α-(trifluoromethyl)benzylamine (1) via biomimetic transamination using chiral base. Imine 4 was isomerized to Schiff base 5 using 50 mol.% of cinchonidine derivatives as a catalyst in chloroform, methanol
Solvent-free stereoselective synthesis of (E)-trifluoromethyl imines and hydrazones
Carroccia, Laura,Fioravanti, Stefania,Pellacani, Lucio,Tardella, Paolo A.
experimental part, p. 4096 - 4100 (2011/02/21)
A new, green and efficient strategy for the synthesis of trifluoromethyl ketimines, aldimines, and hydrazones starting from the corresponding trifluoromethyl carbonyl compounds or their hemiacetals is reported. The condensation reactions were performed under solvent-free conditions with a range of amines or hydrazines and proceeded with high stereoselectivity, always giving only the E-isomer in very good yields. Georg Thieme Verlag Stuttgart - New York.
Thermal 1,3-proton shift reaction and its application for operationally convenient and improved synthesis of α-(trifluoromethyl)benzylamine
Yasumoto, Manabu,Ueki, Hisanori,Soloshonok, Vadim A.
, p. 736 - 739 (2008/03/12)
This paper describes a synthesis of α-(trifluoromethyl)benzylamine via a novel base-free biomimetic reductive amination of α,α,α-trifluoroacetophenone with benzylamine. When the corresponding imine, derived from α,α,α-trifluoroacetophenone and benzylamine
