849774-19-2Relevant academic research and scientific papers
Catalytic asymmetric synthesis of α-(trifluoromethyl)benzylamine via cinchonidine derived base-catalyzed biomimetic 1,3-proton shift reaction
Soloshonok, Vadim A.,Yasumoto, Manabu
, p. 170 - 173 (2007)
Here we describe catalytic asymmetric synthesis of α-(trifluoromethyl)benzylamine (1) via biomimetic transamination using chiral base. Imine 4 was isomerized to Schiff base 5 using 50 mol.% of cinchonidine derivatives as a catalyst in chloroform, methanol
Synthesis of highly 1,3-proton shift transferable N-benzyl imines reaction conditions
Berbasov, Dmitrii O.,Ojemaye, Ifeyinwa D.,Soloshonok, Vadim A.
, p. 603 - 607 (2004)
The standard reaction conditions commonly used for the condensation of carbonyl compounds with amines were found to be synthetically inefficient for preparation of the imines derived from trifluoroacetophenone and benzylamines owing to the susceptibility
Solvent-free stereoselective synthesis of (E)-trifluoromethyl imines and hydrazones
Carroccia, Laura,Fioravanti, Stefania,Pellacani, Lucio,Tardella, Paolo A.
experimental part, p. 4096 - 4100 (2011/02/21)
A new, green and efficient strategy for the synthesis of trifluoromethyl ketimines, aldimines, and hydrazones starting from the corresponding trifluoromethyl carbonyl compounds or their hemiacetals is reported. The condensation reactions were performed under solvent-free conditions with a range of amines or hydrazines and proceeded with high stereoselectivity, always giving only the E-isomer in very good yields. Georg Thieme Verlag Stuttgart - New York.
Synthesis of trifluoromethyl-imines by solid acid/superacid catalyzed microwave assisted approach
Abid, Mohammed,Savolainen, Markku,Landge, Shainaz,Hu, Jinbo,Prakash, G.K. Surya,Olah, George A.,T?r?k, Béla
, p. 587 - 594 (2008/01/01)
A new solid acid/superacid catalyzed microwave assisted synthesis of trifluoromethyl-imines is described. Various α,α,α-trifluoromethylketones react readily with primary amines to produce the corresponding imines. Two different strategies have been employ
Thermal 1,3-proton shift reaction and its application for operationally convenient and improved synthesis of α-(trifluoromethyl)benzylamine
Yasumoto, Manabu,Ueki, Hisanori,Soloshonok, Vadim A.
, p. 736 - 739 (2008/03/12)
This paper describes a synthesis of α-(trifluoromethyl)benzylamine via a novel base-free biomimetic reductive amination of α,α,α-trifluoroacetophenone with benzylamine. When the corresponding imine, derived from α,α,α-trifluoroacetophenone and benzylamine
