1035954-38-1Relevant articles and documents
Enantioselective synthesis of α-trifluoromethyl arylmethylamines by ruthenium-catalyzed transfer hydrogenation reaction
Dai, Xiaoyang,Cahard, Dominique
, p. 1317 - 1328 (2014/05/06)
A simple combination of dichloro(para-cymene)ruthenium(II) dimer, a chiral amino alcohol and isopropyl alcohol allowed for in-situ generation of the bifunctional catalyst responsible for the transfer hydrogenation reaction of trifluoromethyl ketimines in excellent yields with high enantioselectivities (up to 93% ee). Herein, we describe the optimization, scope, limitations, and applications of the method.
Nucleophilic trifluoromethylation of imines under acidic conditions
Levin, Vitalij V.,Dilman, Alexander D.,Belyakov, Pavel A.,Struchkova, Marina I.,Tartakovsky, Vladimir A.
supporting information; experimental part, p. 5226 - 5230 (2009/06/06)
A general method for the trifluoromethylation of imines by using Me 3SiCF3 under acidic conditions is described. The reaction is promoted by hydrofluoric acid generated in situ from KHF2 and either TFA or TfOH. A new chemoselectivity pattern was achieved, as the C=N bond was found to be more reactivate than the carbonyl group. The trifluoromethylation reaction is believed to proceed by concerted transfer of the CF3 group from the silicon atom to the iminium electrophile. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
