849925-84-4Relevant academic research and scientific papers
Fe(III)-Catalyzed Aerobic Intramolecular N-N Coupling of Aliphatic Azides with Amines
Zhang, Yue,Duan, Dongyu,Zhong, Ying,Guo, Xin-Ai,Guo, Jiawei,Gou, Jing,Gao, Ziwei,Yu, Binxun
supporting information, p. 4960 - 4965 (2019/09/03)
An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five- and six-membered semisaturated diazoheterocycles using air as an oxidant is reported, providing an alternative to hydrazine-based methods. Mechanistic studies suggest that a N-radical induced intramolecular homolytic substitution (SH2) is involved in ring closure. The power of this N-N bond-forming method is also demonstrated by using it as the final step in a total synthesis of (-)-newbouldine.
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors
Ahn, Jin Hee,Kim, Jin Ah,Kim, Hye-Min,Kwon, Hyuk-Man,Huh, Sun-Chul,Rhee, Sang Dal,Kim, Kwang Rok,Yang, Sung-Don,Park, Sung-Dae,Lee, Jae Mok,Kim, Sung Soo,Cheon, Hyae Gyeong
, p. 1337 - 1340 (2007/10/03)
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 μM and ED50 value of 80
