849937-09-3

Upstream product

• 78324-07-9 α-<(tert-butyldimethylsiloxy)phenyl>acetyl tert-butydimethylsilyl ester 
• 611-71-2 MANDELIC ACID 
• 148204-86-8 (tert-butyldimethylsilanyloxy)phenylacetic acid methyl ester 

Downstream Products

• 849937-10-6 2-(tert-butyldimethylsilyloxy)-2-phenyl-1-(2-vinylpiperidin-1-yl)ethan-1-one 
• 849937-11-7 2-(tert-butyldimethylsilyloxy)-2-phenyl-1-(2-vinylpyrrolidin-1-yl)ethan-1-one 
• 849937-15-1 (E)-3-(tert-butyldimethylsilyloxy)-2,3,6,7,8,9-hexahydro-3-phenyl-1H-azonine 
• 849937-13-9 (E)-3-(tert-butyldimethylsilyloxy)-1,3,6,7,8,9-hexahydro-3-phenyl-2H-azonin-2-one 
• 849937-14-0 (E)-3-(tert-butyldimethylsilyloxy)-1,2,3,4,7,8,9,10-octahydro-3-phenylazecine 
• 849937-12-8 (E)-3-(tert-butyldimethylsilyloxy)-3,4,7,8,9,10-hexahydro-3-phenylazecin-2(1H)-one 
• 439928-99-1 1,2,3,6,7,8,9,9a-octahydro-3-phenyl-2H-quinolizin-3-ol 
• 1191954-33-2 (S)-2-tert-butyl-6-[(tert-butyldimethylsilyloxy)phenylmethyl]-3-methoxypyridin-4(1H)-one 
• 1191954-39-8 (S,S)-2-tert-butyl-6-[(tert-butyldimethylsilyloxy)phenylmethyl]-3-methoxypyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate 
• 1316312-43-2 (S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine 
• 1316312-45-4 (S)-(6-tert-butyl-4,5-dimethoxypyridin-2-yl)phenylmethanol 

Relevant academic research and scientific papers

Unusual lability of α-silyloxy β-amino carboxylic acid derivatives

Saponification and mild acidification of α-silyloxy homo-arginine derivative 2c revealed an unusual lability of the silyl protecting group. A systematic study of related substrates indicates that hydrogen bonding between the α-amino hydrogen and the carbo

Synthesis of functionalised azecine and azonine derivatives via an enolate assisted aza Claisen rearrangement

This paper describes the synthesis of functionalised azecine and azonine derivatives incorporating the adrenaline motif. In a key step, an enolate assisted aza Claisen rearrangement was employed to interconvert from 6- and 5-membered heterocycles to their corresponding 10- and 9-membered lactams.