84994-64-9

Upstream product

• 70326-39-5 α-benzyloxyhexanal 
• 85027-73-2 (S)-2-O-benzyl-2-hydroxyhexanal 
• 124472-51-1 1,4-di-O-benzyl-octane-1,2,3,4-tetrol 
• 84994-58-1 (R)-1-((S)-2-Phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-pentan-1-ol 

Downstream Products

• 111828-42-3 (2S,1'R)-2-O-benzyl-1-O-N-(1'-phenylethylcarbamoyl)-hexane-1,2-diol 

Relevant academic research and scientific papers

Transformations of Tartaric Acid. Complementary Methods for the Synthesis of Optically Active α-Hydroxyaldehyde Derivatives

Methods for the synthesis of (R)- and (S)-2-benzyloxy and 2-(t-butyldiphenylsilyloxy)-aldehydes from optically active tartaric acids are described.

AN ASYMMETRIC SYNTHESIS OF α-BENZYLOXY ALDEHYDES HAVING A CHIRAL TERTIARY CENTER - AN APPLICATION TO THE ASYMMETRIC SYNTHESIS OF exo-(+)-BREVICOMIN -

α-benzyloxy aldehydes having a chiral tertiary center at α-carbon atom are synthesized in high enantiomeric excess by successive treatment of 2-methoxycarbonyl-3-phenyl-1,3-diazabicyclooctane with diisobutylaluminum hydride (DIBAL-H) and Grignard reagents.The asymmetric reaction is applied to the total synthesis of exo-(+)-brevicomin.