84994-65-0Relevant academic research and scientific papers
An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: Total synthesis of (+)-angustureine
Garg, Yuvraj,Gahalawat, Suraksha,Pandey, Satyendra Kumar
, p. 38846 - 38850 (2015)
A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations incl
AN ASYMMETRIC SYNTHESIS OF α-BENZYLOXY ALDEHYDES HAVING A CHIRAL TERTIARY CENTER - AN APPLICATION TO THE ASYMMETRIC SYNTHESIS OF exo-(+)-BREVICOMIN -
Asami, Masatoshi,Mukaiyama, Teruaki
, p. 93 - 96 (2007/10/02)
α-benzyloxy aldehydes having a chiral tertiary center at α-carbon atom are synthesized in high enantiomeric excess by successive treatment of 2-methoxycarbonyl-3-phenyl-1,3-diazabicyclooctane with diisobutylaluminum hydride (DIBAL-H) and Grignard reagents.The asymmetric reaction is applied to the total synthesis of exo-(+)-brevicomin.
