849948-74-9

Upstream product

• 109425-55-0 Fmoc-Orn(Boc)-OH 
• 100-46-9 benzylamine 

Downstream Products

• 1408237-88-6 C₂₆H₃₄N₄O₃ 
• 1408237-87-5 C₃₅H₄₁N₅O₃ 
• 1408237-89-7 (S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide 
• 1416498-68-4 C₂₆H₃₅N₃O₃ 
• 849948-75-0 N-ε-tert-butoxycarbonyl-L-ornithylbenzylamide 

Relevant academic research and scientific papers

A study on the induction of stereoselectivity in the Strecker synthesis of basic amino acid-derived α-amino nitriles

Diverse basic amino acid-derived α-amino nitriles have been synthesized via a modified Strecker reaction, using TMSCN as the cyanide source. It has been found that this synthesis is a slow thermodynamically controlled reaction, where it was difficult to induce stereocontrol. Moderate selectivity was induced by thermodynamic control of the reaction in MeOH. The absolute configuration at the stereogenic center generated was assigned by chemical correlation with 2-oxopiperazine derivatives.

SOMATOSTATIN RECEPTOR 1 AND/OR 4 SELECTIVE AGONISTS AND ANTAGONISTS

The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.