109425-55-0Relevant articles and documents
Improved scalable syntheses of mono- and bis-urethane derivatives of ornithine
Wiejak,Masiukiewicz,Rzeszotarska
, p. 1189 - 1191 (2001)
In the search for a practical route to ornithine bisurethane derivatives useful for peptide synthesis, we elaborated the simple and efficient (86% yield) synthesis of Nε-tert-butoxycarbonyl-L-ornithine copper(II) complex(1). This served as substrate for obtaining Nε-tert-butoxycarbonyl-L-ornithine (2), Nα-benzyloxycarbonyl-Nε-tert- butoxycarbonyl-L-ornithine (3) and Nα-(9-fluorenyl)methoxycarbonyl-Nε-tert- butoxycarbonyl-L-ornithine (4). These were synthesized in 94-95% yields and with a purity above 99%.
An efficient and economical method for the preparation of Fmoc-Arg ωω (Boc) 2-OH
Zhu, Ruixin,Xie, Ming,Wang, Fei,Liu, Qi,Kang, Tingguo
, p. 1508 - 1509 (2010)
The arginine derivative Fmoc-Arg omega;ω″(Boc) 2-OH has been prepared in perfect yield starting from Fmoc-Orn?HCl and N,N′-di-Boc-N″-triflyguanidine with the presence of diisopropylethylamine (DIEA). This work provides an efficient a
PROPYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF
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Paragraph 0059; 0069; 0073; 0085, (2018/01/13)
A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic peptide lipids are dispersed in water, a cationic liposome with a particle size of approximately 100 nm is obtained. The cationic liposome can carry plasmid DNA (pDNA) or small interfering RNA (siRNA) into cells to realize the function of gene delivery, and is almost non-toxic to the cells.
