849948-90-9Relevant academic research and scientific papers
Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction
Merkx, Remco,Brouwer, Arwin J.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.
, p. 1125 - 1128 (2005)
(Chemical Equation Presented) A highly efficient coupling of protected β-substituted aminoethane sulfonyl azides with thio acids is reported. In the case of peptide thio acids, this method encompasses a new chemoselective ligation method. Furthermore, the
Sulfonyl azides acylsulfonamide derivatives and their use for production of derivative.
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Paragraph 0036-0037, (2017/06/03)
PROBLEM TO BE SOLVED: To provide a click reaction having bioorthogonality and high versatility.SOLUTION: Sulfonyl amidines and acylsulfonamides are manufactured by using thioamide and sulfonyl azide. The reaction is a novel click reacting having no need of additives and bioorthogonality and high versatility with proceeding under a mild condition and in a solution.
'Sulfo-click' for ligation as well as for site-specific conjugation with peptides, fluorophores, and metal chelators
Rijkers, Dirk T. S.,Merkx, Remco,Yim, Cheng-Bin,Brouwer, Arwin J.,Liskamp, Rob M. J.
scheme or table, p. 1 - 5 (2010/11/04)
The 'sulfo-click' reaction, which is a chemoselective amidation reaction involving the reaction of an aminoethane sulfonyl azide with a thio acid, encompasses a new approach for ligation and conjugation. Detailed protocols are provided for decorating biol
Synthesis and applications of β-aminoethanesulfonyl azides
Brouwer, Arwin J.,Merkx, Remco,Dabrowska, Katarzyna,Rijkers, Dirk T. S.,Liskamp, Rob M. J.
, p. 455 - 460 (2007/10/03)
A very efficient method for the synthesis of β-aminoethanesulfonyl azides is descibed. These aliphatic sulfonyl azides are accessible starting from a variety of protected amino acids, including those having functionalized side chains. Furthermore, these s
