850026-81-2Relevant academic research and scientific papers
Formal total synthesis of spirangien A
Gregg, Claire,Gunawan, Christian,Ng, Audrey Wai Yi,Wimala, Samantha,Wickremasinghe, Sonali,Rizzacasa, Mark A.
supporting information, p. 516 - 519 (2013/04/10)
A formal total synthesis of the spiroketal containing cytotoxic myxobacteria metabolite spirangien A (1) is described. The approach utilizes a late introduction of the C20 alcohol that mirrors the biosynthesis of this compound. The key steps involved a hi
Total synthesis of ( - )-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium Cellulosum
Paterson, Ian,Findlay, Alison D.,Noti, Christian
experimental part, p. 594 - 611 (2010/04/23)
An expedient first total synthesis of (-)-spirangien A, a potent cytotoxic and antifungal polyketide of myxobacterial origin, is described. By using a common 1,3-diol intermediate obtained by an efficient aldol-reduction sequence for installation of the C
Total synthesis of pteridic acids A and B
Nakahata, Takashi,Fujimura, Shohei,Kuwahara, Shigefumi
, p. 4584 - 4593 (2008/02/08)
Pteridic acid A (1) is a spirocyclic octaketide produced by the phytoepiphytic actinomycete Streptomyces hygroscopicus TP-A0451 and possesses potent plant-growth-promoting activity comparable to that of indole-3-acetic acid. The enantioselective total syn
Enantioselective total synthesis of pteridic acid A
Nakahata, Takashi,Kuwahara, Shigefumi
, p. 1028 - 1030 (2007/10/03)
Pteridic acid A, a potent plant growth promoter with auxin-like activity, was synthesized enantioselectively by using the Evans asymmetric aldol reaction as the key C-C bond forming step. The Royal Society of Chemistry 2005.
