85003-85-6Relevant articles and documents
Bioactive sulfur-containing sulochrin dimers and other metabolites from an alternaria sp. isolate from a Hawaiian soil sample
Cai, Shengxin,King, Jarrod B.,Du, Lin,Powell, Douglas R.,Cichewicz, Robert H.
, p. 2280 - 2287 (2014)
Polluxochrin (1) and dioschrin (2), two new dimers of sulochrin linked by thioether bonds, were purified from an Alternaria sp. isolate obtained from a Hawaiian soil sample. The structures of the two metabolites were established by NMR, mass spectrometry data, and X-ray analysis. Metabolite 1 was determined to be susceptible to intramolecular cyclization under aqueous conditions, resulting in the generation of 2 as well as another dimeric compound, castochrin (3). An additional nine new metabolites were also obtained, including four new pyrenochaetic acid derivatives (8-11), one new asterric acid analogue (13), and four new secalonic acid analogues (14-17). Bioassay analysis of these compounds revealed 1-3 displayed antimicrobial and weak cytotoxic activities.
