850089-96-2Relevant articles and documents
Promising Antifungal and Antibacterial Agents Based on 5-Aryl-2,2′-bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking
Burgart, Yanina,Shchegolkov, Evgeny,Shchur, Irina,Kopchuk, Dmitry,Gerasimova, Natalia,Borisevich, Sophia,Evstigneeva, Natalia,Zyryanov, Grigory,Savchuk, Maria,Ulitko, Maria,Zilberberg, Natalia,Kungurov, Nikolai,Saloutin, Victor,Charushin, Valery,Chupakhin, Oleg
supporting information, (2021/12/01)
A series of new 5-aryl-2,2′-bipyridines and their (polyfluoro)salicylate complexes of Cu(II), Co(II) and Mn(II) were synthesized. Their antimicrobial activity was evaluated in vitro against six strains of Trichophytons, E. floccosum, M. canis, C. ablicans and Gram-negative bacteria N. gonorrhoeae. Among azo-ligands, Ph-bipy and Tol-bipy showed promising antifungal activity (minimum inhibitory concentration (MIC)4?2H)2(Tol-bipy)2] suppressed the growth of seven Candida strains at MIC 12–24 μM. [Cu(Sal?2H)(Ph-bipy)] and [Cu(SalF3?2H)(Ph-bipy)2] showed the promising anti-gonorrhoeae activity (MIC 4.2–5.2 μM). (Cu(SalFn?2H)(Tol-bipy)2], [Cu(SalF4?2H)(Ph-bipy)2] and [Cu(SalF3?2H)(Ph-bipy)2]) were found active against the bacteria of S. aureus, S. aureus MRSA and their biofilms (MIC 2.4–41.4 μM). The most active compounds were tested for toxicity in vitro against human embryonic kidney (HEK-293) cells and in vivo experiments with CD-1 mice.
Facile synthesis of 6-aryl-3-pyridyl-1,2,4-triazines as a key step toward highly fluorescent 5-substituted bipyridines and their Zn(II) and Ru(II) complexes
Kozhevnikov, Valery N.,Shabunina, Olga V.,Kopchuk, Dmitry S.,Ustinova, Maria M.,K?nig, Burkhard,Kozhevnikov, Dmitry N.
, p. 8963 - 8973 (2008/12/22)
A wide series of substituted bipyridines were obtained through the synthesis of 1,2,4-triazines and their aza Diels-Alder reactions. The reported method facilitates the synthesis of functionally diverse bipyridines that provides fine-tuning of photophysical properties of new ligands and their Zn(II) and Ru(II) complexes. Some of substituted bipyridines exhibit 'off-on' fluorescence response toward Zn2+ cations.
An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines
Kozhevnikov, Valery N.,Kozhevnikov, Dmitry N.,Shabunina, Olga V.,Rusinov, Vladimir L.,Chupakhin, Oleg N.
, p. 1791 - 1793 (2007/10/03)
A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.
