850092-95-4Relevant academic research and scientific papers
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase
Yin, Zheng,Chen, Yen-Liang,Kondreddi, Ravinder Reddy,Chan, Wai Ling,Wang, Gang,Ng, Ru Hui,Lim, Joanne Y. H.,Lee, Wan Yen,Jeyaraj, Duraiswamy A.,Niyomrattanakit, Pornwaratt,Wen, Daying,Chao, Alex,Glickman, J. Fraser,Voshol, Hans,Mueller, Dieter,Spanka, Carsten,Dressler, Sigmar,Nilar, Shahul,Vasudevan, Subhash G.,Shi, Pei-Yong,Keller, Thomas H.
supporting information; experimental part, p. 7934 - 7937 (2010/07/07)
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.
