850144-81-9

Basic information

• Product Name: 2-(4-BROMOPHENYL)-2-METHYLPROPIONAMIDE
• Synonyms: 2-(4-BROMOPHENYL)-2-METHYLPROPIONAMIDE;2-(4-BROMOPHENYL)-2-METHYLPROPANAMIDE;2-(4-bromophenyl)-2-methylpropanamide(SALTDATA: FREE)
• CAS NO: 850144-81-9
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Mol File: 850144-81-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 376.9°C at 760 mmHg
• Flash Point: 181.7°C
• Appearance: /
• Density: 1.398g/cm³
• Vapor Pressure: 7.01E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2-(4-BROMOPHENYL)-2-METHYLPROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOPHENYL)-2-METHYLPROPIONAMIDE(850144-81-9)
• EPA Substance Registry System: 2-(4-BROMOPHENYL)-2-METHYLPROPIONAMIDE(850144-81-9)

Safety Data

• Hazardous Substances Data: 850144-81-9(Hazardous Substances Data)

Usage

Uses

2-(4-Bromophenyl)-2-methylpropanamide (CASs# 850144-81-9) is used in the preparation of substituted pyridopyrazines as SYK inhibitors as well as in the preparation of indazole compounds and isoquinoline derivatives as Rho kinase inhibitors.

InChI:InChI=1/C10H12BrNO/c1-10(2,9(12)13)7-3-5-8(11)6-4-7/h3-6H,1-2H3,(H2,12,13)

Upstream product

• 10519-96-7 potassium trimethylsilonate 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 

Downstream Products

• 214973-83-8 tert-butyl (2-(4-bromophenyl)propan-2-yl)carbamate 
• 1374263-32-7 tert-butyl {1-methyl-1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl]ethyl}carbamate 
• 335592-60-4 tert-butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-propan-2-yl)carbamate 

Relevant articles and documents

ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.