850147-81-8Relevant academic research and scientific papers
Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl 4-PPh3-N-methylimidazole reagent
Iida, Akira,Nakazawa, Syogo,Nakatsuji, Hidefumi,Misaki, Tomonori,Tanabe, Yoo
, p. 48 - 49 (2007/10/03)
Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl 4-PPh3-N-methylimidazole reagent proceeded smoothly to give the α-monosubstituted and thermodynamically unfavorable α,α-
Simple preparation of α-diazo esters
Taber, Douglass F.,Sheth, Ritesh B.,Joshi, Pramod V.
, p. 2851 - 2854 (2007/10/03)
(Chemical Equation Presented) The TiCl4-mediated reaction of an ester with benzoyl chloride results in high yields of the α-benzoylated ester. Diazo transfer of the benzoylated ester utilizing p- acetoamidobenzenesulfonyl azide affords the α-diazo ester in good yield. Using this simplified procedure, it is easy to prepare gram quantities of α-diazo esters.
