39959-94-9

Usage

Uses

Used in Pharmaceutical Research:
2-chloro-3-(trifluoromethyl)benzamide is utilized as a key intermediate in the development of new pharmaceuticals, contributing to the creation of innovative drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2-chloro-3-(trifluoromethyl)benzamide serves as a crucial building block for the synthesis of various agrochemicals, enhancing crop protection and yield.
Used in Organic Synthesis:
2-chloro-3-(trifluoromethyl)benzamide is employed as a versatile intermediate in organic synthesis, allowing for the production of a wide range of chemical compounds with diverse applications in various industries.

InChI:InChI=1/C8H5ClF3NO/c9-6-4(7(13)14)2-1-3-5(6)8(10,11)12/h1-3H,(H2,13,14)

Upstream product

• 39226-97-6 2-chloro-3-trifluoromethylbenzoic acid 
• 313-12-2 2-amino-3-(trifluoromethyl)benzoic acid 
• 391-12-8 7-trifluoromethylisatin 
• 850156-39-7 2-chloro-3-(trifluoromethyl)benzoyl chloride 

Downstream Products

• 39226-96-5 2-chloro-3-(trifluoromethyl)benzylamine 
• 62584-32-1 2-chloro-3-trifluoromethylbenzonitrile 
• 936220-62-1 2-chloro-N-[(dimethylamino)methylene]-3-(trifluoromethyl)benzamide 
• 899431-48-2 5-(2-chloro-3-trifluoromethylphenyl)-1H-tetrazole 

Relevant academic research and scientific papers

Concise preparation of a stable cyclic sulfamidate intermediate in the synthesis of a enantiopure chiral active diamine derivative

A classical resolution was studied and developed from 2-benzoyl-pyridine in order to prepare SSR504734, a novel antipsychotic derivative. The key step of this route is the substitution of a sulfamidate derivative by a benzamide anion with complete inversi

P2X7 receptor antagonists and methods of use

The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 /sub

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists

1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X? receptor. Structure-activity relationship (SAR) studies were conducted around both the benzyl and phenyl moieties. In addition, the importance of the regiochemical substitution

THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS

The present invention relates to the use of selective P2X7 receptor antagonists of formula (I), or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration.