850161-81-8

Basic information

• Product Name: L-Phenylalanine, 4-iodo-N-methyl-N-(trifluoroacetyl)-, methyl ester
• CAS NO: 850161-81-8
• Molecular Formula: C13H13F3INO3
• Molecular Weight: 415.151
• Mol File: 850161-81-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, 4-iodo-N-methyl-N-(trifluoroacetyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, 4-iodo-N-methyl-N-(trifluoroacetyl)-, methyl ester(850161-81-8)
• EPA Substance Registry System: L-Phenylalanine, 4-iodo-N-methyl-N-(trifluoroacetyl)-, methyl ester(850161-81-8)

Safety Data

• Hazardous Substances Data: 850161-81-8(Hazardous Substances Data)

Upstream product

• 115820-04-7 N-trifluoroacetyl-4-iodophenylalanine 
• 74-88-4 methyl iodide 

Downstream Products

• 138571-42-3 N-BOC-N-methyl-4-iodo-L-phenylalanine 
• 850161-83-0 N-Boc-N-methyl-4-iodophenylalanine methyl ester 
• 850161-82-9 N-methyl-4-iodophenylalanine 

Relevant articles and documents

N-methylsansalvamide a peptide analogues. Potent new antitumor agents

Sansalvamide A, a cyclic depsipeptide isolated from a marine fungus of the genus Fusarium, is composed of four hydrophobic amino acids (Phe, two Leu, Val) and one hydroxy acid ((S)-2-hydroxy-4-methylpentanoic acid; O-Leu) with five stereogenic centers all having S-stereochemistry. We have recently synthesized the corresponding cyclic peptide (Gu, W.; Liu, S.; Silverman, R. B. Organic Lett. 2002, 4, 4171-4174) and found that it too has antitumor activity. N-Methylation can enhance potency and selectivity for peptides. Consequently, here we synthesize 12 different N-methylated sansalvamide A peptide analogues and show that for several different tumor cell lines three of these analogues are more potent than the natural product; in pancreatic cells, sansalvamide A shows little activity, but the N-methylsansalvamide peptides are potent cytotoxic agents.