850161-82-9 Usage
Uses
Used in Pharmaceutical Synthesis:
4-iodo-N-methylphenylalanine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to enhance the properties of drug molecules, such as increasing their stability, solubility, or bioavailability.
Used in Peptide Synthesis:
In the field of peptide synthesis, 4-iodo-N-methylphenylalanine is utilized as a building block to create novel peptides with specific biological activities, contributing to the development of new therapeutic agents.
Used in Protein and Peptide Modification:
4-iodo-N-methylphenylalanine is employed as a modifying agent in the alteration of proteins and peptides, enabling researchers to study their structure-function relationships and develop new biotechnological applications.
Used in Research Applications:
As a versatile compound, 4-iodo-N-methylphenylalanine is used in research for probing the mechanisms of various biological processes and for the development of new diagnostic tools and therapeutic strategies.
Used in Drug Discovery:
4-iodo-N-methylphenylalanine is used as a starting material in drug discovery, facilitating the design and synthesis of new drug candidates with potential therapeutic benefits for treating specific diseases and disorders.
Used in Organic Chemistry:
In the realm of organic chemistry, 4-iodo-N-methylphenylalanine is utilized in the synthesis of various organic compounds, demonstrating its versatility and importance in the development of new chemical entities.
Overall, 4-iodo-N-methylphenylalanine is a multifaceted chemical compound with a broad range of applications across different industries, including pharmaceuticals, biotechnology, and organic chemistry. Its potential in therapeutic applications and its role as a building block in the synthesis of various compounds make it an indispensable component in the advancement of scientific research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 850161-82-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,0,1,6 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 850161-82:
(8*8)+(7*5)+(6*0)+(5*1)+(4*6)+(3*1)+(2*8)+(1*2)=149
149 % 10 = 9
So 850161-82-9 is a valid CAS Registry Number.
850161-82-9Relevant academic research and scientific papers
CYCLIC PEPTIDE ANTITUMOR AGENTS
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Page/Page column 11-12; 16, (2010/02/11)
Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
N-methylsansalvamide a peptide analogues. Potent new antitumor agents
Liu, Shouxin,Gu, Wenxin,Lo, Denise,Ding, Xian-Zhong,Ujiki, Michael,Adrian, Thomas E.,Soff, Gerald A.,Silverman, Richard B.
, p. 3630 - 3638 (2007/10/03)
Sansalvamide A, a cyclic depsipeptide isolated from a marine fungus of the genus Fusarium, is composed of four hydrophobic amino acids (Phe, two Leu, Val) and one hydroxy acid ((S)-2-hydroxy-4-methylpentanoic acid; O-Leu) with five stereogenic centers all having S-stereochemistry. We have recently synthesized the corresponding cyclic peptide (Gu, W.; Liu, S.; Silverman, R. B. Organic Lett. 2002, 4, 4171-4174) and found that it too has antitumor activity. N-Methylation can enhance potency and selectivity for peptides. Consequently, here we synthesize 12 different N-methylated sansalvamide A peptide analogues and show that for several different tumor cell lines three of these analogues are more potent than the natural product; in pancreatic cells, sansalvamide A shows little activity, but the N-methylsansalvamide peptides are potent cytotoxic agents.
