85020-87-7Relevant academic research and scientific papers
Concomitant ring contraction cyclization strategy for the synthesis of novel 4-oxo-4,5-dihydro-pyrroloquinolines
Manh, Gabriel Thia,Bakkali, Hicham,Maingot, Lucie,Pipelier, Muriel,Joshi, Uday,Pradère, Jean Paul,Sabelle, Stéphane,Tuloup, Remy,Dubreuil, Didier
, p. 5913 - 5916 (2007/10/03)
The synthesis of novel substituted pyrroloquinolinones is described by concomitant ring contraction cyclization form 2-(2-amino-5-nitro-phenyl)-[4H]-1, 3-thiazines, which were derived from N-substituted 5-nitro-anthranilonitrile. An easy access to novel 4-thiono-1,4-dihydro-1,3-quinazoline heterocycles is also mentioned.
REACTION OF 2,4-DISUBSTITUTED CHLOROBENZENES WITH 3-ALKYLAMINO- AND 3-DIALKYLAMINOPROPIONITRILES
Plakidin, Val. L.,Vostrova, V. N.
, p. 295 - 303 (2007/10/02)
The reaction of 2,4-disubstituted chlorobenzenes with 3-dialkylaminopropionitriles at 65-170 deg C leads to the formation of 2,4-disubstituted N,N-dialkylanilines, and the reaction with 3-alkylaminopropionitriles at 20-130 deg C leads to the formation of 2,4-disubstituted N-alkyl-N-β-cyanoethylanilines.In addition, in the latter case at high temperature (130 deg C) the cyanoethyl group is removed from the substituted N-alkyl-N-β-cyanoethylaniline with the formation of the 2,4-disubstituted N-alkylaniline.
