850221-69-1Relevant academic research and scientific papers
Palladium-catalyzed cross-coupling of aroyl chlorides with aryl stannanes in the presence of triethylsilane: Efficient access to aromatic ketones
Higashi, Shoko,Uno, Sota,Ohsuga, Yui,Noumi, Maiko,Saito, Ryota
supporting information, (2020/10/12)
Herein, we report the development of a palladium-catalyzed cross-coupling reaction that focuses on the preparation of aromatic ketones. Aroyl chlorides react quickly at 120 °C with aryl stannanes in the presence of Pd(PPh3)4 and Et3SiH to efficiently give the corresponding ketones without the formation of significant decarbonylated byproducts. In other words, the decarbonylative side reaction is practically suppressed by simply adding Et3SiH to the reaction mixture, which reduces the amount of biaryl impurities in the products.
Synthesis and in vitro evaluation of botryllazine B analogues as a new class of inhibitor against human aldose reductase
Saito, Ryota,Tokita, Mai,Uda, Keisuke,Ishikawa, Chikako,Satoh, Mitsutoshi
scheme or table, p. 3019 - 3026 (2009/06/18)
Botryllazine B analogues of diverse substitution patterns have been prepared, and their in vitro inhibitory activities against recombinant human aldose reductase (h-ALR2) evaluated. Among the 15 compounds tested, 6-(4-aminophenyl)-2-(4-hydroxyphenyl)carbonylpyrazine (7b) proved to be the most potent inhibitor, with IC50=0.91 μM. Kinetic analyses of 7b and botryllazine B (1) revealed that these inhibitors exhibit an unprecedented mixed-type inhibition on h-ALR2 with respect to the substrate d,l-glyceraldehyde, in the presence of NADPH at inhibitor concentrations near the IC50 values.
Synthesis of pyrazine alcaloids from Botryllus leachi. diazines 43
Buron, Frederic,Ple, Nelly,Turck, Alain,Queguiner, Guy
, p. 2616 - 2621 (2007/10/03)
(Chemical Equation Presented) Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.
