850306-79-5Relevant academic research and scientific papers
Flexible synthesis of polyfunctionalised 3-fluoropyrroles
Cogswell, Thomas J.,Donald, Craig S.,Marquez, Rodolfo
, p. 183 - 190 (2015/12/30)
An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes. The methodology is concise, efficient and allows for the modular and systematic assembly of polysubstituted 3-fluoropyrroles. This synthesis provides an alternative and highly convergent strategy for the generation of these chemically and biologically important units.
Iridium-catalyzed asymmetric allylic substitutions-very high regioselectivity and air stability with a catalyst derived from dibenzo[a,e]cyclooctatetraene and a phosphoramidite
Spiess, Stephanie,Welter, Carolin,Franck, Geraldine,Taquet, Jean-Philippe,Helmchen, Guenter
supporting information; scheme or table, p. 7652 - 7655 (2009/04/11)
A final tweak: A new phosphoramidite iridium catalyst (see scheme) allows allylic substitutions to be run with a higher degree of regioselectivity than with other iridium catalysts and under aerobic conditions. Mechanistic aspects, in particular, the reversibility of the catalyst formation by C-H activation, are also presented. LL=dibenzocyclooctatetraene.
