850311-51-2

Basic information

• Product Name: Ethanol, 2-[(2,4-dimethoxyphenyl)amino]-
• CAS NO: 850311-51-2
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.234
• Mol File: 850311-51-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[(2,4-dimethoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(2,4-dimethoxyphenyl)amino]-(850311-51-2)
• EPA Substance Registry System: Ethanol, 2-[(2,4-dimethoxyphenyl)amino]-(850311-51-2)

Safety Data

• Hazardous Substances Data: 850311-51-2(Hazardous Substances Data)

Upstream product

• 2735-04-8 2,4-Dimethoxyaniline 
• 540-51-2 2-bromoethanol 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 141-43-5 ethanolamine 

Downstream Products

• 890129-67-6 (2-bromo-ethyl)-(2,4-dihydroxy-phenyl)-carbamic acid benzyl ester 
• 1422463-41-9 2-(2-((2-((2,4-dimethoxyphenyl)amino)ethyl)amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione 

Relevant articles and documents

Development of unsymmetrical dyads as potent noncarbohydrate-based inhibitors against human β-N-acetyl-D-hexosaminidase

Human β-N-acetyl-D-hexosaminidase has gained much attention due to its roles in several pathological processes and been considered as potential targets for disease therapy. A novel and efficient skeleton, which was an unsymmetrical dyad containing naphthalimide and methoxyphenyl moieties with an alkylamine spacer linkage as a noncarbohydrate-based inhibitor, was synthesized, and the activities were valuated against human β-N-acetyl-D- hexosaminidase. The most potent inhibitor exhibits high inhibitory activity with Ki values of 0.63 μM. The straightforward synthetic manners of these unsymmetrical dyads and understanding of the binding model could be advantageous for further structure optimization and development of new therapeutic agents for Hex-related diseases.

BICYCLIC AMIDES AS KINASE INHIBITORS

The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.

Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles

CuI-catalyzed coupling reaction of electron-deficient aryl iodides with aliphatic primary amines occurs at 40 °C under the promotion of N-methylglycine. Using L-proline as the promoter, coupling reaction of aryl iodides or aryl bromides with aliphatic primary amines, aliphatic cyclic secondary amines, or electron-rich primary arylamines proceeds at 60-90 °C; an intramolecular coupling reaction between aryl chloride and primary amine moieties gives indoline at 70 °C; coupling reaction of aryl iodides with indole, pyrrole, carbazole, imidazole, or pyrazole can be carried out at 75-90 °C; and coupling reaction of electron-deficient aryl bromides with imidazole or pyrazole occurs at 60-90 °C to provide the corresponding N-aryl products in good to excellent yields. In addition, N,N-dimethylglycine promotes the coupling reaction of electron-rich aryl bromides with imidazole or pyrazole to afford the corresponding N-aryl imidazoles or pyrazoles at 110 °C. The possible action of amino acids in these coupling reactions is discussed.