850404-92-1

Basic information

• Product Name: 2H-Pyran-2-acetonitrile, 5,6-dihydro-6-[(2R)-2-methoxy-4-(phenylmethoxy)butyl]-, (2S,6S)-
• CAS NO: 850404-92-1
• Molecular Formula: C19H25NO3
• Molecular Weight: 315.412
• Mol File: 850404-92-1.mol

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-2-acetonitrile, 5,6-dihydro-6-[(2R)-2-methoxy-4-(phenylmethoxy)butyl]-, (2S,6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-acetonitrile, 5,6-dihydro-6-[(2R)-2-methoxy-4-(phenylmethoxy)butyl]-, (2S,6S)-(850404-92-1)
• EPA Substance Registry System: 2H-Pyran-2-acetonitrile, 5,6-dihydro-6-[(2R)-2-methoxy-4-(phenylmethoxy)butyl]-, (2S,6S)-(850404-92-1)

Safety Data

• Hazardous Substances Data: 850404-92-1(Hazardous Substances Data)

Upstream product

• 850404-91-0 2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester 
• 143-33-9 sodium cyanide 
• 850404-89-6 (2S,3S)-2,4,6-trimethylbenzenesulfonic acid 3-(dimethylphenylsilanyl)-2-(trimethylsilanyloxy)pent-4-enyl ester 
• 850405-01-5 2,4,6-Trimethyl-benzenesulfonic acid (2S,3S)-3-(dimethyl-phenyl-silanyl)-2-hydroxy-pent-4-enyl ester 
• 850405-00-4 (2S,3S)-3-(Dimethyl-phenyl-silanyl)-pent-4-ene-1,2-diol 

Downstream Products

• 850404-87-4 [4-(tert-butyldiphenylsilanyloxy)-6-(2-methoxy-4-oxobutyl)-tetrahydro-2H-pyran-2-yl]acetonitrile 
• 850404-95-4 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(R)-4-hydroxy-2-methoxybutyl]-tetrahydro-2H-pyran-2-yl}acetonitrile 
• 850404-94-3 {(2S,4S,6R)-6-[(R)-4-benzyloxy-2-methoxybutyl]-4-(tert-butyldiphenylsilanyloxy)tetrahydro-2H-pyran-2-yl}acetonitrile 
• 850404-98-7 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(2S)-3-((2R,3S,6S)-6-formyl-3-methyltetrahydro-2H-pyran-2-yl)-2-methoxypropyl]tetrahydro-2H-pyran-2-yl}acetonitrile 
• 850404-85-2 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(2S)-2-methoxy-3-((2R,3S,6S)-3-methyl-6-(oxoethyl)tetrahydro-2H-pyran-2-yl)propyl]tetrahydro-2H-pyran-2-yl}acetonitrile 
• 850404-96-5 (2S,5S,6R)-6-{(2S)-3-[(2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-cyanomethyltetrahydro-2H-pyran-2-yl]-2-methoxypropyl}-5-methyl-5,6-dihydro-2H-pyran-2-carboxylic acid isopropyl ester 
• 850404-97-6 (2S,5S,6R)-6-{(2S)-3-[(2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-cyanomethyltetrahydro-2H-pyran-2-yl]-2-methoxypropyl}-5-methyltetrahydro-2H-pyran-2-carboxylic acid isopropyl ester 
• 862846-88-6 (1R,3S,5R,7R,9R,13R,15S,18S)-7-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-18-methyl-13-((E)-4-methyl-pent-1-enyl)-12,19,20-trioxa-tricyclo[13.3.1.1^5,9]icosan-11-ol 
• 850404-99-8 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(2S)-3-((2R,3S,6S)-6-((2R,3E)-2-hydroxy-6-methylhept-3-enyl)-3-methyltetrahydro-2H-pyran-2-yl)-2-methoxypropyl]tetrahydro-2H-pyran-2-yl}acetonitrile 
• 321667-28-1 (1R,3S,5R,7R,9R,13R,15S,18S)-7-(tert-butyldiphenylsilanyloxy)-3-methoxy-18-methyl-13-((E)-4-methylpent-1-enyl)-12,19,20-trioxatricyclo[13.3.1.1^5,9]icosan-11-one 
• 850404-93-2 {(2S,4S,6S)-6-[(R)-4-benzyloxy-2-methoxybutyl]-4-hydroxytetrahydro-2H-pyran-2-yl}acetonitrile 

Relevant articles and documents

[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A

Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un

Total synthesis of (+)-leucascandrolide A

A convergent and enantioselective total synthesis of (+)-leucascandrolide (1) was accomplished in 17 steps. Central to this synthesis is the rapid and efficient integration of the bispyran moiety into 1 using two consecutive [4 + 2] annulation reactions b