850425-50-2

Upstream product

• 193967-71-4 bromo<(S)-(1-phenylethyl)carbamoyl>methane 
• 850425-51-3 dimethoxyphosphoryl-N-[(S)-α-methylbenzyl]acetamide 
• 74-88-4 methyl iodide 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 850425-48-8 C₂₀H₂₆NO₄P 
• 850425-49-9 C₂₀H₂₆NO₄P 

Relevant academic research and scientific papers

Asymmetric alkylation of dimethoxyphosphoryl-N-[1-(S)-α-methyl- benzyl]acetamide enolates. Synthesis of both stereoisomers from the same source of chirality by changing the equivalents of LDA

A new methodology has been developed for the synthesis of both stereoisomers from a single chiral source. The Royal Society of Chemistry 2005.

Reversal of diastereoselectivity in the benzylation of the lithium enolates of phosphonopropanoamides by changing the base equivalents

Phosphonopropanoamides bearing (S)-α-methylbenzylamine were easily obtained, and the benzylation of their enolates examined. Surprisingly, a reversal of the π-facial diastereoselectivity was observed by changing the number of equivalents of the lithium ba

Practical and efficient synthesis of (E)-α,β-unsaturated amides bearing (S)-α-methylbenzylamine from 2-phosphonamides via Horner-Wadsworth-Emmons reaction

The highly stereoselective synthesis of (E)-α,β-unsaturated amides bearing (S)-α-methylbenzylamine was achieved from 2-phosphonamides via Horner-Wadsworth-Emmons reaction. The starting phosphonamides are easily prepared in two steps with excellent yields