850427-69-9Relevant academic research and scientific papers
Lysine-spermine conjugates: Hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
Burns, Mark R.,Wood, Stewart J.,Miller, Kelly A.,Nguyen, Thuan,Cromer, Jens R.,David, Sunil A.
, p. 2523 - 2536 (2005)
Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are outer-membrane constituents of Gram-negative bacteria. Lipopolysaccharides play a key role in the pathogenesis of 'Septic Shock', a major cause of mortality in the critically ill patient. Thera
Hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
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Page/Page column 6; sheet 8, (2010/11/08)
Lysine-spermine conjugates with a long-chain aliphatic (C12-C20) substituent at R1 bind and neutralize bacterial lipopolysaccharides. These compounds reduce lethality in a murine model of lipopolysaccharide-induced shock,
