850429-60-6

Basic information

• Product Name: Methyl 2-amino-5-bromothiazole-4-carboxylate
• Synonyms: 2-AMINO-5-BROMOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER;METHYL 2-AMINO-5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE;METHYL 2-AMINO-5-BROMOTHIAZOLE-4-CARBOXYLATE;METHYL 2-AMINO-5-BROMO-4-THIAZOLECARBOXYLATE;Methyl 2-amino-5-bromothiazole-4-carboxylat;Methyl 2-amino-5-bromo-1,3-thiazole-4-carboxylate 95%;4-Thiazolecarboxylicacid,2-amino-5-bromo-,methylester(9CI);2-Amino-5-bromo-4-(methoxycarbonyl)-1,3-thiazole
• CAS NO: 850429-60-6
• Molecular Formula: C5H5BrN2O2S
• Molecular Weight: 237.07
• Product Categories: THIAZOLE;Amines;blocks;Bromides;Carboxes;Thiazoles;Aromatic Esters;Methyl 2-Amino-5-Bromothiazole-4-Carboxylate ada@tuskwei.com
• Mol File: 850429-60-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 157-159
• Boiling Point: 349.3 °C at 760 mmHg
• Flash Point: 165 °C
• Appearance: /
• Density: 1.844 g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.74±0.10(Predicted)
• CAS DataBase Reference: Methyl 2-amino-5-bromothiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-5-bromothiazole-4-carboxylate(850429-60-6)
• EPA Substance Registry System: Methyl 2-amino-5-bromothiazole-4-carboxylate(850429-60-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 850429-60-6(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-5-bromothiazole-4-carboxylate is a chemical compound with the molecular formula C7H6BrN2O2S. It is a derivative of thiazole, a heterocyclic compound containing a five-membered ring with sulfur and nitrogen atoms. Methyl 2-amino-5-bromothiazole-4-carboxylate is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of various biologically active molecules. It possesses an amino group, a carboxylate group, and a bromine atom, all of which contribute to its diverse reactivity and potential applications in organic synthesis. Additionally, the methyl ester group makes it more soluble in organic solvents, allowing for ease of manipulation in laboratory settings.

InChI:InChI=1/C5H5BrN2O2S/c1-10-4(9)2-3(6)11-5(7)8-2/h1H3,(H2,7,8)

Upstream product

• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 

Downstream Products

• 81569-26-8 5-isopropyl-thiazole-4-carboxylic acid methyl ester 
• 913836-22-3 5-bromothiazole-4-carboxylic acid methyl ester 
• 63257-03-4 methyl 2-amino-5-methyl-1,3-thiazole-4-carboxylate 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).