913836-22-3

Usage

Uses

Used in Pharmaceutical Research:
METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97 is used as a key intermediate in the synthesis of various pharmaceutical compounds for its unique structural and functional properties. Its presence in the molecular structure can influence the pharmacokinetics and pharmacodynamics of the resulting drugs, enhancing their therapeutic potential.
Used in Agrochemical Development:
In the agrochemical industry, METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97 is used as a building block in the creation of novel agrochemicals, such as pesticides and herbicides. Its unique chemical properties allow for the development of more effective and targeted agrochemicals, improving crop protection and yield.
Used in Organic Synthesis:
METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97 is utilized as a versatile reagent in organic synthesis, enabling the formation of a wide range of chemical products. Its bromine atom and carboxylate ester group facilitate various chemical reactions, making it a valuable component in the synthesis of complex organic molecules for diverse applications.

InChI:InChI=1/C5H4BrNO2S/c1-9-5(8)3-4(6)10-2-7-3/h2H,1H3

Upstream product

• 850429-60-6 methyl 2-amino-5-bromo-thiazole-4-carboxylate 
• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 67-56-1 methanol 
• 103878-58-6 5-bromo-1,3-thiazole-4-carboxylic acid 

Downstream Products

• 81569-26-8 5-isopropyl-thiazole-4-carboxylic acid methyl ester 
• 912639-68-0 (5-bromothiazol-4-yl)methanol 
• 1239464-24-4 methyl 5-amino-1,3-thiazole-4-carboxylate 
• 103878-58-6 5-bromo-1,3-thiazole-4-carboxylic acid 
• 1107646-64-9 methyl 5-(4-tert-butylphenyl)thiazole-4-carboxylate 

Relevant academic research and scientific papers

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

THERAPEUTIC KINASE MODULATORS

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules.

PROTEIN KINASE MODULATORS

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.

HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.