913836-22-3

Basic information

• Product Name: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97
• Synonyms: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97;Methyl 5-bromo-1,3-thiazole-4-carboxylate 97%;5-Bromo-4-(methoxycarbonyl)-1,3-thiazole
• CAS NO: 913836-22-3
• Molecular Formula: C₅H₄BrNO₂S
• Molecular Weight: 222.0616
• Product Categories: blocks;Bromides;Carboxes;Thiazoles;Building Blocks;Thiazole
• Mol File: 913836-22-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-101
• Boiling Point: 276℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.759
• Vapor Pressure: 0.00492mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Keep Cold
• PKA: -1.48±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97(913836-22-3)
• EPA Substance Registry System: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97(913836-22-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 913836-22-3(Hazardous Substances Data)

Usage

General Description

Methyl 5-Bromo-1,3-Thiazole-4-Carboxylate 97 is a chemical compound with the molecular formula C6H5BrNO2S. It is a derivative of thiazole, containing a bromine atom and a carboxylate ester functional group. METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97 is commonly used in organic synthesis and pharmaceutical research, particularly in the development of new drugs and agrochemicals. It is a highly pure form of the chemical, with a purity of at least 97%, making it suitable for use in advanced research and industrial applications.

InChI:InChI=1/C5H4BrNO2S/c1-9-5(8)3-4(6)10-2-7-3/h2H,1H3

Upstream product

• 850429-60-6 methyl 2-amino-5-bromo-thiazole-4-carboxylate 
• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 67-56-1 methanol 
• 103878-58-6 5-bromo-1,3-thiazole-4-carboxylic acid 

Downstream Products

• 81569-26-8 5-isopropyl-thiazole-4-carboxylic acid methyl ester 
• 912639-68-0 (5-bromothiazol-4-yl)methanol 
• 1239464-24-4 methyl 5-amino-1,3-thiazole-4-carboxylate 
• 103878-58-6 5-bromo-1,3-thiazole-4-carboxylic acid 
• 1107646-64-9 methyl 5-(4-tert-butylphenyl)thiazole-4-carboxylate 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

PROTEIN KINASE MODULATORS

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.

SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.