85053-10-7Relevant academic research and scientific papers
Diverse ring opening of thietanes and other cyclic sulfides: An electrophilic aryne activation approach
Zheng, Tianyu,Tan, Jiajing,Fan, Rong,Su, Shuaisong,Liu, Binbin,Tan, Chen,Xu, Kun
supporting information, p. 1303 - 1306 (2018/02/14)
Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two
Synthesis of (+)-Lentiginosine and Its Pyrrolizidine Analogue Based on Intramolecular Cyclization of α-Sulfinyl Carbanions
Du-A-Man, Sakkarin,Soorukram, Darunee,Kuhakarn, Chutima,Tuchinda, Patoomratana,Reutrakul, Vichai,Pohmakotr, Manat
, p. 1708 - 1715 (2015/10/05)
A synthesis of (+)-lentiginosine and its pyrrolizidine analogue was accomplished in six steps, starting from L-(+)-tartaric acid. The key step of these syntheses involves the intramolecular cyclization of α-sulfinyl carbanions for the construction of the indolizidine or pyrrolizidine ring.
Neutral sulfur nucleophiles: Synthesis of thioethers and thioesters by substitution reactions of N-heterocyclic carbene boryl sulfides and thioamides
Pan, Xiangcheng,Curran, Dennis P.
supporting information, p. 2728 - 2731 (2014/06/09)
Newly discovered boryl sulfides and N-borylthioamides are shown to serve as neutral sources of sulfur nucleophiles in substitutions reactions. For example, heating of diMe-Imd-BH(SPh)2 with benzyl bromides, primary bromides, or acid chlorides provides the corresponding thioethers or thioesters in high yields. Likewise, N-phenyltetrazole thioethers/esters are made from a readily available N-borylthionotetrazole. The formation of the boryl sulfide and its onward nucleophilic substitution can be telescoped down to a one-pot reaction whose components are an NHC-borane (NHC-BH3), a disulfide, and an electrophile.
Synthesis, spectral studies and C-S, C-N bond fissions of some novel N-[alkyl (4′-substituted phenylthio)] phthalimides
El-Bardan, Ali A.
, p. 511 - 519 (2007/10/03)
N-[(4′-Substituted phenylthio)ethyl] phthalimide la-g and their corresponding n-propyl 2a-g, n-butyl 3a-g derivatives have been synthesised. The structure of these compounds were proved by UV, IR, 1H NMR, 13CMR and mass spectra. The 1H and 13C chemical shifts of the adjacent methylene protons and carbons of both the sulfur atom and phthalimido nitrogen group were reasonably correlated using σ° values. The carbon-nitrogen and the carbon-sulfur bond fissions in alkaline and acidic media were discussed.
Inhibition of adhesion molecule expression by N-alkylthiopyridine-benzo[b]thiophene-2-carboxamides
Boschelli, Diane H.,Connor, David T.,Lesch, Mark E.,Schrier, Denis J.
, p. 557 - 562 (2007/10/03)
The surface levels of ICAM-1 and E-selectin on activated endothelial cells can be reduced by 3-alkoxybenzo[b]thiophene-2-carboxamides. This property is shared by several N-alkylthiopyridine substituted imides. Combining structural elements of these two diverse series lead to a new class of small molecule inhibitors of adhesion molecule expression.
Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones
-
, (2008/06/13)
The present invention relates to new compounds of the formula STR1 and the pharmaceutically acceptable salts thereof and the enantiomers thereof, wherein R1 is H, lower alkyl, alkenyl, aralkyl, or C(O)R2 wherein R2 is lowe
N-(arylthioalkyl)-N'-(aminoalkyl)ureas
-
, (2008/06/13)
N-(arylthioalkyl)-N'-(aminoalkyl)ureas and thioureas and oxidation derivatives having the formula STR1 wherein B is thio, sulfinyl or sulfonyl; R1 and R2 are hydrogen, loweralkyl, cycloalkyl, 2-furanyl, phenyl, substituted phenyl or phenyl-loweralkyl and R3 and R4 are hydrogen, loweralkyl, phenyl or phenyl-loweralkyl wherein phenyl is optionally substituted, or R3 and R4 taken with the adjacent nitrogen form a heterocyclic residue.
