850554-43-7

Upstream product

• 850554-42-6 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide 
• 124-63-0 methanesulfonyl chloride 
• 288104-75-6 4-(4-bromo-phenyl)-2-[(2,4-dichloro-phenyl)-hydrazono]-3-methyl-4-oxo-butyric acid ethyl ester 
• 850554-40-4 1-(2,4-dichloro-phenyl)-4-methyl-5-{4-[5-(tetrahydro-pyran-2-yloxy)-pentyl]-phenyl}-1H-pyrazole-3-carboxylic acid ethyl ester 
• 850554-41-5 1-(2,4-dichloro-phenyl)-4-methyl-5-{4-[5-(tetrahydro-pyran-2-yloxy)-pentyl]-phenyl}-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide 
• 10342-83-3 4'-Bromopropiophenone 
• 821-09-0 n-Pent-4-enyl alcohol 
• 183232-62-4 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 850554-45-9 5-[4-(5-azido-pentyl)-phenyl]-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide 

Relevant academic research and scientific papers

Synthesis of novel 5-substituted pyrazole derivatives as cannabinoid antagonists

A facile seven-step sequence was developed from 4′- bromopropiophenone, utilizing a Suzuki-type coupling with an alkene, to give several novel 5-substituted pyrazole derivatives in overall yields of 11-31%. They are potent CB1 antagonists and have binding