850607-60-2Relevant academic research and scientific papers
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD
Wan, Zehong,Laine, Dramane I.,Yan, Hongxing,Zhu, Chongjie,Widdowson, Katherine L.,Buckley, Peter T.,Burman, Miriam,Foley, James J.,Sarau, Henry M.,Schmidt, Dulcie B.,Webb, Edward F.,Belmonte, Kristen E.,Palovich, Michael
, p. 4560 - 4562 (2009)
Design and syntheses of a novel series of muscarinic antagonists are reported. These efforts have culminated in the discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide (4a) as a potent and pan-active musca
Design, synthesis, and structure - Activity relationship of tropane muscarinic acetylcholine receptor antagonists
Lainé, Dramane I.,Wan, Zehong,Yan, Hongxing,Zhu, Chongjie,Xie, Haibo,Fu, Wei,Busch-Petersen, Jakob,Neipp, Christopher,Davis, Roderick,Widdowson, Katherine L.,Blaney, Frank E.,Foley, James,Bacon, Alicia M.,Webb, Edward F.,Luttmann, Mark A.,Burman, Miriam,Sarau, Henry M.,Salmon, Michael,Palovich, Michael R.,Belmonte, Kristen
experimental part, p. 5241 - 5252 (2010/03/02)
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure - activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very pot
