Bioorganic and Medicinal Chemistry Letters p. 4560 - 4562 (2009)
Update date:2022-09-26
Topics:
Wan, Zehong
Laine, Dramane I.
Yan, Hongxing
Zhu, Chongjie
Widdowson, Katherine L.
Buckley, Peter T.
Burman, Miriam
Foley, James J.
Sarau, Henry M.
Schmidt, Dulcie B.
Webb, Edward F.
Belmonte, Kristen E.
Palovich, Michael
Design and syntheses of a novel series of muscarinic antagonists are reported. These efforts have culminated in the discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide (4a) as a potent and pan-active musca
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