850615-89-3Relevant academic research and scientific papers
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors
Sabatucci, Joseph P.,Mahaney, Paige E.,Leiter, Jennifer,Johnston, Grace,Burroughs, Kevin,Cosmi, Scott,Zhang, Yingru,Ho, Douglas,Deecher, Darlene C.,Trybulski, Eugene
scheme or table, p. 2809 - 2812 (2010/08/21)
A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.
1- 2’ (1, 4’-BIPERIDIN-1’-YL)-1- (PHENYL) -ETHYL CYCLOHEXANOL DERIVATIVES AS MONOAMINE REUPTAKE MODULATORS FOR THE TREATMENT OF VISOMOTOR SYMPTOMS
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Page/Page column 56, (2008/06/13)
The present invention is directed to substituted N-heterocycle derivatives of formula (I), compositions containing these derivatives, and their use in the manufacture of a medicament for the prevention and treatment of conditions ameliorated by monoamine
ARYLALKYL- AND CYCLOALKYLALKYL-PIPERAZINE DERIVATIVES AND METHODS OF THEIR USE
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Page/Page column 56, (2008/06/13)
The present invention is directed to arylalkyl- and cycloalkylalkyl-piperazine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, int
SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE
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Page/Page column 59, (2008/06/13)
The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,vas
Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
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Page/Page column 15, (2010/02/14)
The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including,
