850623-45-9

Usage

Uses

Used in Pharmaceutical Industry:
POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is used as a key reagent in the synthesis of pharmaceutical compounds for its ability to facilitate the formation of complex organic molecules that are essential in the creation of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is utilized as a reagent in the production of various agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Material Science:
POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is employed as a component in the synthesis of functional polymers, which are crucial for the advancement of material science and the creation of new materials with specific properties.
Used in Specialty and Fine Chemicals Production:
POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is also used as a reagent in the manufacture of specialty and fine chemicals, where its high reactivity and stability are advantageous for producing high-quality and specialized chemical products.
Overall, POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE plays a significant role across various industries, particularly in organic chemistry, where it contributes to the advancement and innovation of numerous applications.

Downstream Products

• 1017601-67-0 C₂₆H₂₄N₂O₃ 
• 1207290-79-6 benzyl 4-(2,2,6-trimethyl-4-oxo-4H-1,3-dioxin-5-yl)phenylcarbamate 
• 1226980-82-0 C₂₀H₁₉NO₃ 

Relevant academic research and scientific papers

Functionalization of (2S)-Isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4- ones by a Suzuki-Miyaura Cross-Coupling Reaction Using Aryltrifluoroborate Salts: Convenient Enantioselective Preparation of α-Substituted β-Amino Acids

A simple protocol for the Pd(OAc)2-catalyzed cross-coupling reaction of 1-benzoyl-(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-ones with potassium aryltrifluoroborates was developed. The reaction is performed at 110°C with a ligand-free catalyst. In all cases, complete conversion of the 1-benzoyl-(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-onesand aryltrifluoroborates into the C-C coupling products was observed within 30-360 min. It is noteworthy that a largevariety of groups present in the potassium aryltrifluoroborates (-CF3, -OMe, -SEt, -CN, -CHO, -Cl, -Cbz, -NCbz,-OH, -CO2H) could be tolerated. Hydrogenation of the endocyclic double bonds in the Suzuki-Miyaura products followed by acid hydrolysis afforded highly enantioenrichedα-aryl-substituted β-amino acids. We present a general approach for the synthesis of (2S)-isopropyl-5-aryl-2,3- dihydro-4(H)-pyrimidin-4-ones by Suzuki-Miyaura reaction of aryltrifluoroborate salts with(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-ones in the presence of a palladium catalyst and a base. The arylated compounds were transformed into enantioenriched α-aryl-substituted β-amino acids. Copyright

Highly efficient palladium-catalyzed Suzuki-Miyaura reactions of potassium aryltrifluoroborates with 5-iodo-1,3-dioxin-4-ones in water: an approach to α-aryl-β-ketoesters

The high efficient palladium-catalyzed Suzuki-Miyaura reactions of potassium aryltrifluoroborates 3 with 5-iodo-1,3-dioxin-4-ones 2a-b in water as only solvent in the presence of n-Bu4NOH as base is reported. The respective 5-aryl-1,3-dioxin-4-ones 4a-n were obtained in good to excellent yields. The catalyst system provides high efficiency at low load using electronically diverse coupling partners. The obtained 2,2,6-trimethyl-5-aryl-1,3-dioxin-4-ones were transformed into corresponding α-aryl-β-ketoesters 6 by reaction with an alcohol in the absence of solvent.