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850628-99-8

4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester is a complex organic compound with a molecular formula of C30H36N6O3. It is a derivative of pyrido[2,3-d]pyrimidin, featuring a cyclopentyl and methyl group, an acetyl group, and a piperazine ring. 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester is characterized by its 7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino structure, which is crucial for its biological activity. It is often found in the form of a tert-butyl ester, which is a protective group used in organic synthesis to prevent unwanted reactions at the carboxylic acid group. 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester is of interest in medicinal chemistry due to its potential as a precursor in the development of pharmaceuticals, particularly those targeting kinase enzymes, which are involved in various diseases. The ester group can be removed under acidic conditions to yield the free carboxylic acid, which may be further used in the synthesis of drugs or other bioactive molecules.

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  • 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester

    Cas No: 850628-99-8

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  • 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester

    Cas No: 850628-99-8

  • Need to discuss

  • No requirement

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  • Xinyang Longye Chemical CO.,LTD
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  • 850628-99-8 Structure

  • Basic information

    1. Product Name: 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester
    2. Synonyms: 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester
    3. CAS NO:850628-99-8
    4. Molecular Formula:
    5. Molecular Weight: 546.67
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 850628-99-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester(850628-99-8)
    11. EPA Substance Registry System: 4-[4-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester(850628-99-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 850628-99-8(Hazardous Substances Data)

850628-99-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 850628-99-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,0,6,2 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 850628-99:
(8*8)+(7*5)+(6*0)+(5*6)+(4*2)+(3*8)+(2*9)+(1*9)=188
188 % 10 = 8
So 850628-99-8 is a valid CAS Registry Number.

850628-99-8Downstream Products

850628-99-8Relevant articles and documents

Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4

VanderWel, Scott N.,Harvey, Patricia J.,McNamara, Dennis J.,Repine, Joseph T.,Keller, Paul R.,Quin III, John,Booth, R. John,Elliott, William L.,Dobrusin, Ellen M.,Fry, David W.,Toogood, Peter L.

, p. 2371 - 2387 (2007/10/03)

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]-pyrimidin-7-one template has been identified previously as a privileged structure for the inhibition of ATP-dependent kinases, and good potency against Cdks has been reported for representative examples. Obtaining selectivity for individual Cdk enzymes, particularly Cdk4, has been challenging. Here, we report that the introduction of a methyl substituent at the C-5 position of the pyrido[2,3-d]pvrimidin-7-one template is sufficient to confer excellent selectivity for Cdk4 vs other Cdks and representative tyrosine kinases. Further optimization led to the identification of highly potent and selective inhibitors of Cdk4 that exhibit potent antiproliferative activity against human tumor cells in vitro. The most selective Cdk4 inhibitors were evaluated for antitumor activity against MDA-MB-435 human breast carcinoma xenografts in mice.

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