850635-49-3Relevant academic research and scientific papers
Structure-based optimization of a non-β-lactam lead results in inhibitors that do not up-regulate β-lactamase expression in cell culture
Tondi, Donatella,Morandi, Federica,Bonnet, Richard,Costi, M. Paola,Shoichet, Brian K.
, p. 4632 - 4639 (2005)
Bacterial expression of β-lactamases is the most widespread resistance mechanism to β-lactam antibiotics, such as penicillins and cephalosporins. There is a pressing need for novel, non-β-lactam inhibitors of these enzymes. One previously discovered novel
