850635-69-7

Upstream product

• 710351-78-3 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxamide 
• 611226-09-6 4-(4-(methylamino)-3-nitrophenoxy)pyridine-2-carboxylic acid 
• 220000-86-2 tert-butyl 4-chloropyridine-2-carboxylate 
• 850713-40-5 C₁₃H₁₀N₆O₄ 
• 611225-63-9 tert-butyl 4-(4-(methylamino)-3-nitrophenoxy)picolinate 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 611225-60-6 tert-butyl 4-(4-amino-3-nitrophenoxy)picolinate 
• 850713-41-6 tert-butyl (4-(4-(methylamino)-3-nitrophenoxy)pyridin-2-yl)carbamate 

Downstream Products

• 850713-44-9 1-methyl-N-(4-{[4-(methylamino)-3-nitrophenyl]oxy}pyridin-2-yl)piperidine-4-carboxamide 
• 850713-46-1 ((1-ethyl)(4-piperidyl))-N-{4-[4-(methylamino)-3-nitrophenoxy](2-pyridyl)}carboxamide 
• 850713-48-3 N-{4-[4-(methylamino)3-nitrophenoxy](2-pyridyl)}-[1-(methylethyl)(4-piperidyl)]carboxamide 
• 850713-50-7 [1-(2-methoxyethyl)(4-piperidyl)]-N-{4-[4-(methylamino)-3-nitrophenoxy](2-pyridyl)}carboxamide 
• 850713-49-4 N-{4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-[1-(methylethyl)(4-piperidyl)]carboxamide 
• 850713-45-0 N-(4-{[3-amino-4-(methylamino)phenyl]oxy}pyridin-2-yl)-1-methylpiperidine-4-carboxamide 

Relevant academic research and scientific papers

Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE

New substituted benzazole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additi