220000-86-2

Basic information

• Product Name: 4-Chloropyridine-2-carboxylic acid tert-butyl ester
• Synonyms: 4-Chloropyridine-2-carboxylic acid tert-butyl ester;tert-butyl 4-chloropicolinate;tert-Butyl 4-chloropyridine-2-carboxylate
• CAS NO: 220000-86-2
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.67
• Product Categories: API intermediates
• Mol File: 220000-86-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 295.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.10±0.10(Predicted)
• CAS DataBase Reference: 4-Chloropyridine-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carboxylic acid tert-butyl ester(220000-86-2)
• EPA Substance Registry System: 4-Chloropyridine-2-carboxylic acid tert-butyl ester(220000-86-2)

Safety Data

• Hazardous Substances Data: 220000-86-2(Hazardous Substances Data)

Usage

Uses

tert-Butyl 4-Chloropicolinate is used in the synthetic preparation of 2-aminobenzimidazoles as Raf kinase inhibitors.

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 75-65-0 tert-butyl alcohol 
• 399-95-1 4-amino-3-fluorophenol 
• 5470-22-4 4-chloropicolinic acid 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 865-48-5 sodium t-butanolate 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 98-98-6 2-Picolinic acid 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 868171-68-0 tert-butyl 4-aminopicolinate 
• 611225-60-6 tert-butyl 4-(4-amino-3-nitrophenoxy)picolinate 
• 1097726-88-9 tert-butyl 4-(4-aminophenoxy)picolinate 
• 1097726-89-0 tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate 
• 1012058-78-4 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic acid 
• 573673-43-5 methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate 
• 611226-25-6 4-(4-Methylamino-3-nitro-phenoxy)-pyridine-2-carbaldehyde 
• 611226-24-5 (4-(4-(methylamino)-3-nitrophenoxy)pyridin-2-yl)methanol 
• 850713-49-4 N-{4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-[1-(methylethyl)(4-piperidyl)]carboxamide 
• 850713-45-0 N-(4-{[3-amino-4-(methylamino)phenyl]oxy}pyridin-2-yl)-1-methylpiperidine-4-carboxamide 
• 850713-48-3 N-{4-[4-(methylamino)3-nitrophenoxy](2-pyridyl)}-[1-(methylethyl)(4-piperidyl)]carboxamide 

Relevant articles and documents

PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR

Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is -NH-phenyl-CH2-O-; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., -OC(O)-. ????????Lacto-XAN-PABC-Z?????(Formula A)

METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED OMEGA-DIPHENYLUREA

Methods and processes for preparation and production of deuterated ω-diphenylurea are disclosed. Especially, a kind of deuterated ω-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenye-N′-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.

SORAFENIB DERIVATIVES AS sEH INHIBITORS

The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.