85072-41-9

Upstream product

• 95-73-8 2,4-dichlorotoluene 
• 7149-77-1 1,5-dichloro-2-methyl-4-nitrobenzene 

Downstream Products

• 85072-42-0 3,5'-dimethyl-4,2',4'-trichlorodiphenylether 
• 798552-93-9 1',2'-dideoxy-1'-(2,4-dichloro-5-methylphenyl)-β-D-ribofuranose 
• 798552-98-4 3',5'-O-((1,1,3,3-tetraisopropyl)disiloxane-1,3-diyl)-1',2'-dideoxy-1'-(2,4-dichloro-5-methylphenyl)-β-D-ribofuranose 

Relevant academic research and scientific papers

A set of nonpolar thymidine nucleoside analogues with gradually increasing size

(Chemical Equation Presented) We describe a series of nonpolar nucleoside analogues having similar shapes and gradually increasing size. The structure of the nucleobase thymine was mimicked with toluene derivatives, replacing 02/04 with hydrogen, fluorine, chlorine, bromine, and iodine. Glycosidic bonds were formed by reactions of lithiated 2,4-dihalotoluenes with a deoxyribonolactone derivative. Structural analysis by NMR showed similar conformations across the series. The compounds are useful for study of the biological recognition of nucleotides and nucleic acids.

Process for the nuclear chlorination of toluene

Para-chlorotoluene is prepared selectively at high yield by nuclear chlorination of toluene, in the presence of a Lewis acid catalyst, and a co-catalyst comprising at least one compound selected from the group consisting of phenoxthine derivatives and hig