85078-20-2

Usage

Chemical structure

A benzene ring with a methoxy group at the 1-position and a 1-(4-methoxyphenyl)-2-nitro-butyl group at the 4-position.

Usage

Mainly used in organic synthesis and pharmaceutical industries.

Physical appearance

Pale yellow solid.

Molecular weight

293.33 g/mol.

Melting point

100-102°C.

Application

Often used as an intermediate in the production of various pharmaceuticals and agrochemicals.

Safety precautions

Handle with care as it can be hazardous if not used properly.

Upstream product

• 36462-38-1 1-(4-Methoxyphenyl)-2-nitrobutanol 
• 100-66-3 methoxybenzene 

Relevant academic research and scientific papers

Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: Concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes

Benzylic alcohols carrying an adjacent α-nitro or α-azido group on the alkane chain are converted into syn-1,1-diaryl-2-nitro- and 2-azidoalkanes with electron-rich arenes in stereoselective reactions catalyzed by Bronsted and Lewis acids. Gold(III) chloride and bismuth(III) triflate were found to be especially efficient as catalysts, showing kinetically controlled differentiation in the reactivity of diastereomeric α-substituted benzyl alcohols. Applications to therapeutically relevant syn- and anti- 2-amino-1,1-diarylalkanes are projected.