850786-05-9

Upstream product

• 536-74-3 phenylacetylene 
• 177838-10-7 (E)-N-(2,2,2-trifluoroethylidene)-4-methoxyaniline 
• 204130-91-6 4-methoxy-N-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)aniline 
• 99333-34-3 N-(2,2,2-trifluoroethylidene)-4-methoxyaniline 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1111327-24-2 3-iodo-6-methoxy-4-phenyl-2-(trifluoromethyl)quinoline 
• 1033193-13-3 (4-methoxyphenyl)[(Z)-3-phenyl-1-(trifluoromethyl)allyl]amine 
• 1033193-20-2 (4-methoxyphenyl)[(E)-3-phenyl-1-(trifluoromethyl)allyl]amine 

Relevant academic research and scientific papers

Cu(I)-Catalyzed gem-Aminoalkynylation of Diazo Compounds: Synthesis of Fluorinated Propargylic Amines

The gem-aminoalkynylation of fluorinated diazo compounds catalyzed by a simple Cu(I) salt is described. This three-component reaction allows the synthesis of propargylic amines with broad functional group tolerance. Both electron-rich and electron-poor an

Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation

A highly enantioselective synthesis of chiral fluorinated propargylamines was developed through phosphoric acid and ruthenium-catalyzed chemoselective biomimetic hydrogenation of the carbon-nitrogen double bond of fluorinated alkynyl ketimines in the presence of a carbon-carbon triple bond. This reaction features high chemoselectivity and slow background reaction. In addition, selective transformations of the chiral fluorinated propargylamines were also reported.

Synthesis of 2-trifluoromethyl quinoline by the reaction of fluorinated imine with alkyne catalyzed by indium(III) triflate

Preparation of 2-trifluoromethyl-4-aryl quinolines from a variety of readily available alkynes and N-aryl trifluoroethylimine has been achieved via indium(III) triflate catalyzed Diels-Alder reactions. Georg Thieme Verlag Stuttgart New York.

Synthesis of highly substituted 2-perfluoroalkyl quinolines by electrophilic iodocyclization of perfluoroalkyl propargyl imines/amines

A series of highly substituted 2-perfluoroalkyl-3-iodoquinolines are prepared by two different methods in good to excellent yields under mild reaction conditions. The first method involves iodocyclization of perfluoroalkyl propargyl imines with I2/s

Stereoselective access to substituted [(E)- or (Z)-1-(trifluoromethyl)- allyl]amines

Hydrometallation reactions, for example, hydroboration and hydroalumination, on [1-(trifluoromethyl)propargyl]amines lead stereoselectively to the corresponding [(Z)- and (E)-1-(trifluoromethyl)allyl]amines in good yields; (Z)- and (E)-allylamines with a free amino group can be obtained in good yields and excellent enantioselectivities from the chiral propargylamines. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Direct access to CF3-propargyl amines and conversion to difluoromethyl imines

Trifluoromethyl aldimines reacted with acetylides in toluene at -78°C to provide propargyl amines in good yields. From a chiral trifluoromethyl aldimine, the propargyl amines were obtained with excellent diastereoselectivities (de >98%). Trifluoromethyl p