177838-10-7

Basic information

• Product Name: Benzenamine, 4-methoxy-N-(2,2,2-trifluoroethylidene)-, (E)-
• CAS NO: 177838-10-7
• Molecular Formula: C9H8F3NO
• Molecular Weight: 203.164
• Mol File: 177838-10-7.mol

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-methoxy-N-(2,2,2-trifluoroethylidene)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-methoxy-N-(2,2,2-trifluoroethylidene)-, (E)-(177838-10-7)
• EPA Substance Registry System: Benzenamine, 4-methoxy-N-(2,2,2-trifluoroethylidene)-, (E)-(177838-10-7)

Safety Data

• Hazardous Substances Data: 177838-10-7(Hazardous Substances Data)

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 104-94-9 4-methoxy-aniline 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 75999-66-5 (Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 850786-05-9 (4-methoxyphenyl)-(3-phenyl-1-trifluoromethyl-prop-2-ynyl)-amine 
• 62158-95-6 4-methoxy-N-(2,2,2-trifluoroethyl)aniline 
• 592537-94-5 N-(4-methoxyphenyl)-N-[1-(trifluoromethyl)-3-butenyl]amine 
• 832722-39-1 N-(4-methoxyphenyl)-N-[1-(trifluoromethyl)prop-2-enyl]acetamide 

Relevant articles and documents

Facile preparation of polyfluoroalkylated aldimines from polyfluoroalkanoic acids

Polyfluoroalkylated aldimines were prepared by reducing polyfluoroalkyl imidoyl chlorides, which are readily available from polyfluoroalkanoic acids, with LTBA (lithium tri-tert-butoxyaluminum hydride). Georg Thieme Verlag Stuttgart.

Synthesis of fluoro-substituted 4,5-dihydro-1,2,4-oxadiazoles via 1,3-dipolar cycloadditions

4,5-Dihydro-1,2,4-oxadiazoles have been prepared by regiospecific 1,3-dipolar cycloaddition of nitrile oxides with fluoro-substituted aldimines.

Chiral sulfoxide controlled asymmetric additions to C-N double bond. An efficient approach to stereochemically defined α-fluoroalkyl amino compounds

This paper presents a full account of studies into the asymmetric addition reactions between α-lithium derivatives of enantiomerically pure methyl and benzyl p-tolyl sulfoxides and the N-(p-methoxyphenyl)aldimines, bearing trifluoromethyl, pentafluoroethy

Diastereoselective Synthesis of the Nonracemic Methyl syn-(3-Fluoroalkyl)isoserinates

Cycloaddition of the (fluoroalkyl)imines 7a-c with the ketene formed in situ from (benzyloxy)acetyl chloride and triethylamine provided stereoselectively cis-(fluoroalkyl)azetidinones 5a-c in moderate yields. The corresponding N-Boc-isoserinates 11a-c and protected synthons 12a-c have been prepared from these azetidinones 5a-c. Cycloaddition of the chiral imine 18 (RF = CF3) with the same ketene led to the diastereoisomeric azetidinones 19 and 20 with a poor diastereoisomeric excess (10-20%) However, the two diastereoisomers could be easily separated by crystallization and provided enantiomerically pure N-Boc-isoserinates 23 (R,R) and 23 (S,S) after ring opening and debenzylation.