850799-82-5Relevant academic research and scientific papers
Stereocontrolled photodimerization of (E)-3-benzylidene-4-chromanones in the crystalline state: The effect of a halogen group on the chromanone moiety
Cheng, Xue-Ming,Chen, Min,Huang, Zhi-Tang,Zheng, Qi-Yu
, p. 3693 - 3698 (2013/02/22)
A series of (E)-3-benzylidene-4-chromanone derivatives are synthesized, which are substituted with a halogen group on the chromanone moiety in order to control the molecular arrangement in the crystalline state. The stereoselective photoreactions of these compounds in the solid state are examined based on the crystal structures of the reactants and products. All the examples tested undergo photodimerization, except for (E)-3-benzylidene-6-fluorochroman-4-one. The reactants with β-structures give syn-head-to-head (syn-HH) products with high selectivity. Only (E)-6-chloro-3-(4-methylbenzylidene)-chroman-4-one adopted the α-form and gives an anti-head-to-tail (anti-HT) product. Georg Thieme Verlag KG Stuttgart · New York.
N-heterocyclic carbene-catalyzed cascade reaction involving the hydroacylation of unactivated alkynes
Biju, Akkattu T.,Wurz, Nathalie E.,Glorius, Frank
supporting information; experimental part, p. 5970 - 5971 (2010/07/05)
The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide α,β-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of a
MITOTIC KINESIN INHIBITORS
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Page/Page column 42, (2008/06/13)
The present invention relates to tricyclic pyrazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions whic
