850804-19-2

Basic information

• Product Name: Acetamide, N-[3,5-dimethoxy-2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]-
• CAS NO: 850804-19-2
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol File: 850804-19-2.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[3,5-dimethoxy-2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[3,5-dimethoxy-2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]-(850804-19-2)
• EPA Substance Registry System: Acetamide, N-[3,5-dimethoxy-2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]-(850804-19-2)

Safety Data

• Hazardous Substances Data: 850804-19-2(Hazardous Substances Data)

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 
• 256642-33-8 2′-amino-4′,6′-dimethoxyacetophenone 
• 850804-18-1 1-(2-amino-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 850804-20-5 N-{2-[3,3-dimethoxy-2-(4-methoxyphenyl)propionyl]-3,5-dimethoxyphenyl}acetamide 
• 850804-22-7 1-ethyl-5,7-dihydroxy-3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1621002-97-8 5,7-dihydroxy-3-(4-hydroxyphenyl)-1-propyl-1H-quinolin-4-one 
• 190774-10-8 5,7-dimethoxy-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 190774-11-9 5,7-dimethoxy-3-(4-methoxyphenyl)-1-methyl-1H-quinolin-4-one 
• 850804-23-8 1-ethyl-5,7-dimethoxy-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 1621002-89-8 5,7-dimethoxy-3-(4-methoxyphenyl)-1-propyl-1H-quinolin-4-one 

Relevant articles and documents

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular modeling study showed putative binding modes of the compound 3a in the active site of ERα and ERβ, which were similar with that of genistein and provided insight of the effect of N-alkyl substitution of azaisoflavones on ERβ activity. Also, a biphasic effect of azaisoflavone analogs on MCF-7 cell growth depending on their concentrations was investigated.

Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC50 7.83 μM for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS.