190774-11-9

Upstream product

• 190774-10-8 5,7-dimethoxy-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 74-88-4 methyl iodide 
• 256642-33-8 2′-amino-4′,6′-dimethoxyacetophenone 
• 850804-18-1 1-(2-amino-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 850804-19-2 N-{3,5-dimethoxy-2-[3-(4-methoxyphenyl)acryloyl]phenyl}acetamide 
• 850804-20-5 N-{2-[3,3-dimethoxy-2-(4-methoxyphenyl)propionyl]-3,5-dimethoxyphenyl}acetamide 
• 10272-07-8 3.5-dimethoxyaniline 
• 101987-52-4 ethyl α-(hydroxymethylene)-4-methoxyphenylacetate 
• 190774-07-3 (Z)-ethyl 3-((3,5-dimethoxyphenyl)amino)-2-(4-methoxyphenyl)acrylate 

Relevant academic research and scientific papers

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular modeling study showed putative binding modes of the compound 3a in the active site of ERα and ERβ, which were similar with that of genistein and provided insight of the effect of N-alkyl substitution of azaisoflavones on ERβ activity. Also, a biphasic effect of azaisoflavone analogs on MCF-7 cell growth depending on their concentrations was investigated.

Pharmaceutical compositions comprising 4-quinolones for treating cancers

A non-cytotoxic pharmaceutical composition acting on the proliferation of clonogenic cells in malignant tumors and including an efficient amount of a compound selected among the compounds of formula (I) and (Ia).

Synthesis of 3-(4-methoxyphenyl)-5,7-dimethoxy-(1H)-quinolin-2- or 4-ones and derivatives

Condensation of ethyl 2-(4-methoxyphenyl)-3-hydroxyacrylate with 3,5-dimethoxyaniline afforded, depending on experimental conditions, either 3-(4-methoxyphenyl)-5,7-dimethoxy-(1H)-quinolin-2-one or 3-(4-methoxyphenyl)-5,7-dimethoxy-(1H)-quinolin-4-one. Whereas chlorination with phosphorous oxychloride led to the corresponding 2- and 4- chloroquinolines derivatives, 2-chloro-3-(4-methoxyphenyl)-5,7-dimethoxyquinoline was also obtained by using the Meth Cohn method's.