850884-06-9Relevant academic research and scientific papers
HIV-1 replication inhibitors of the styrylquinoline class: Introduction of an additional carboxyl group at the C-5 position of the quinoline
Zouhiri, Fatima,Danet, Michèle,Bénard, Christophe,Normand-Bayle, Marie,Mouscadet, Jean-Fran?ois,Leh, Hervé,Marie Thomas, Claire,Mbemba, Gladys,D'Angelo, Jean,Desma?le, Didier
, p. 2201 - 2205 (2007/10/03)
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class, bearing an additional acid group or a propenoic acid moiety at the C-5 position of the quinoline have been synthesized. Key steps included Heck reaction and palladium catalyzed carbonylation reaction of 5-haloquinaldine derivatives. These compounds exhibited reinforced anti-integrase potency and significant antiviral activities.
