85098-70-0

Basic information

• Product Name: 1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE
• Synonyms: 4-AMINO-1-[2-(4-METHOXYPHENYL)ETHYL]PIPERIDINE;4-AMINO-1-(4-METHOXYPHENETHYL)PIPERIDINE;1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE;1-[2-(4-METHOXYPHENYL)ETHYL]-4-AMINOPIPERIDINE;1-[2-(4-methoxyphenyl)ethyl]piperidin-4-amine;1-[2-(4-Methoxyphenyl)ethyl]-4-piperidinamine;Einecs 285-422-5;4-Amino-1-(4-methoxyphenethyl)piperidine 1-(4-Methoxyphenethyl)-4-aminopiperidine 1-[2-(4-Methoxyphenyl)ethyl]-4-aminopiperidine
• CAS NO: 85098-70-0
• Molecular Formula: C₁₄H₂₂N₂O
• Molecular Weight: 234.34
• EINECS: 285-422-5
• Mol File: 85098-70-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 30-32 °C
• Boiling Point: 346.6 °C at 760 mmHg
• Flash Point: 163.4 °C
• Appearance: /
• Density: 1.03 g/cm³
• Vapor Pressure: 5.68E-05mmHg at 25°C
• Refractive Index: 1.533
• PKA: 10.49±0.20(Predicted)
• CAS DataBase Reference: 1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE(85098-70-0)
• EPA Substance Registry System: 1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE(85098-70-0)

Safety Data

• Hazardous Substances Data: 85098-70-0(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenethyl)-4-aminopiperidine is a chemical compound that consists of a piperidine ring with an amino group, connected to a phenethyl group which has a methoxy group attached to it. 1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE is an intermediate in the synthesis of pharmaceutical drugs and is used in the research and development of various medications. It is known for its potential use as a medication for disorders such as schizophrenia, depression, and other central nervous system conditions. This chemical may also have potential use in the treatment of chronic pain and neurodegenerative diseases. However, further research and clinical trials are needed to fully elucidate its pharmacological properties and potential therapeutic applications.

InChI:InChI=1/C14H22N2O/c1-17-14-4-2-12(3-5-14)6-9-16-10-7-13(15)8-11-16/h2-5,13H,6-11,15H2,1H3

Upstream product

• 1610561-19-7 tert-butyl (1-(4-methoxyphenenyl)piperidin-4-yl)carbamate 
• 18217-00-0 1-(2-Chloroethyl)-4-methoxybenzene 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 39742-51-3 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 39742-63-7 1-[2-(4-methoxyphenyl)ethyl]-4-piperidone 

Downstream Products

• 108555-25-5 1-(4-methoxyphenethyl)piperidin-4-amine hydrochloride 
• 68844-77-9 astemizole 
• 104472-63-1 (1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine 

Relevant articles and documents

2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

A compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species

The in vitro neuronal cell death model based on the HT22 mouse hippocampal cell model is a convenient means of identifying compounds that protect against oxidative glutamate toxicity which plays a role in the development of certain neurodegenerative diseases. Functionalized acridin-9-yl-phenylamines were found to protect HT22 cells from glutamate challenge at submicromolar concentrations. The Aryl1-NH-Aryl2 scaffold that is embedded in these compounds was the minimal pharmacophore for activity. Mechanistically, protection against the endogenous oxidative stress generated by glutamate did not involve up-regulation of glutathione levels but attenuation of the late stage increases in mitochondrial ROS and intracellular calcium levels. The NH residue in the pharmacophore played a crucial role in this regard as seen from the loss of neuroprotection when it was structurally modified or replaced. That the same NH was essential for radical scavenging in cell-free and cell-based systems pointed to an antioxidant basis for the neuroprotective activities of these compounds.

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.