851-32-1Relevant academic research and scientific papers
Copper(II)-Promoted, One-Pot Conversion of 1-Alkynes with Anhydrides or Primary Amines to the Respective 2,5-Disubstituted Furans or Pyrroles under Microwave Irradiation Conditions
Lee, Hyejeong,Yi, Yeonhui,Jun, Chul-Ho
, p. 3485 - 3490 (2015)
Furans and pyrroles are prepared from 1-alkynes by using a Cu(II)-promoted, one-pot, microwave irradiation method. Glaser coupling of 1-alkynes and cyclization of the resulting 1,3-diyne in the presence of an anhydride or a primary amine results in the formation of the respective 2,5-diaryl- or 2,5-dialkyl-substituted furans and pyrroles.
Synthesis of Substituted Pyrroles by Intramolecular Condensation of a Wittig Reagent with the Carbonyl Group of a Tertiary Amide
Cooney, John V.,McEwen, William E.
, p. 2570 - 2573 (2007/10/02)
1,2,5-Trisubstituted pyrroles are obtained in 50-100percent yields by addition of the conjugate bases of open-chain analogues of Reissert compounds to the vinyltriphenylphosphonium cation, with subsequent cyclization by an intramolecular Wittig reaction and base-catalyzed elimination of hydrogen cyanide.
