851010-69-0Relevant academic research and scientific papers
Kinetic resolution of sec-alcohols using a new class of readily assembled (S)-proline-derived 4-(pyrrolidino)-pyridine analogues
Dalaigh, Ciaran O.,Hynes, Stephen J.,Maher, Declan J.,Connon, Stephen J.
, p. 981 - 984 (2005)
We report the development of a new class of readily prepared chiral 4-(pyrrolidino)-pyridine catalysts capable of exploiting both van der Waals (π) and H-bonding interactions, thus allowing remote chiral information to stereo-chemically control the kinetic resolution of sec-alcohols. The Royal Society of Chemistry 2005.
Asymmetric acyl-transfer promoted by readily assembled chiral 4-N,N-dialkylaminopyridine derivatives
Dalaigh, Ciaran O.,Hynes, Stephen J.,O'Brien, John E.,McCabe, Thomas,Maher, Declan J.,Watson, Graeme W.,Connon, Stephen J.
, p. 2785 - 2793 (2008/03/14)
The development of a new class of chiral 4-N,N-dialkylaminopyridine acyl-transfer catalysts capable of exploiting both van der Waals (π) and H-bonding interactions to allow remote chiral information to stereochemically control the kinetic resolution of sec-alcohols with moderate to excellent selectivity (s = 6-30). Catalysts derived from (S)-α,α- diarylprolinol are considerably superior to analogues devoid of a tertiary hydroxyl moiety and possess high activity and selectivity across a broad range of substrates. The Royal Society of Chemistry 2006.
