851028-60-9

Usage

Molecular Structure

A complex organic compound derived from L-pyroglutamic acid with a formyl and a tert-butyl ester group attached to the 2-position of the pyrrolidine ring.

Usage in Industries

Commonly used in pharmaceutical and cosmetic industries as a building block for drug synthesis and as a moisturizing and anti-aging ingredient in skincare products.

Neuroprotective Properties

The compound has been studied for its potential neuroprotective properties, making it an area of interest for research in neuroscience and drug development.

Cognitive-Enhancing Properties

The compound has also been researched for its potential to enhance cognitive function, further contributing to its importance in the field of neuroscience.

Upstream product

• 109837-32-3 methyl (S)-2-methylpyrrolidine-2-carboxylate 
• 220060-17-3 (S)-1-tert-butyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate 
• 103336-06-7 N-(tert-butoxycarbonyl)-2-methyl-L-proline 
• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1339022-10-4 tert-butyl (2S)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate 

Downstream Products

• 1339021-85-0 (S)-benzyl (7a-methyl-1-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizin-3-yl)(3-methylbut-2-enoyl)carbamate 
• 1339021-94-1 (S)-3-amino-7a-methyl-5,6,7,7a-tetrahydro-1H-pyrrolizin-1-one 
• 1339022-13-7 potassium (S)-7a-methyl-1-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylate 
• 1339338-97-4 C₉H₁₁NO₃ 
• 1339021-78-1 (S)-benzyl (7a-methyl-1-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizin-3-yl)carbamate 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED SULFONYLUREA DERIVATIVES

The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as the compounds of the invention belong to the family of NOD-like receptor family (NLR) protein NLRP3 modulators. The present invention thus relates to novel NLRP3 modulators as well as to the use of the novel inhibitor compounds in the treatment of diseases or conditions in which interleukin 1β activity is implicated.

Benzimidazole-2-piperazine compound, its pharmaceutical composition and its preparation and use

The invention relates to a benzimidazole-2-piperazine derivative and a preparing method and application of the benzimidazole-2-piperazine derivative in medicine, in particular to a novel benzimidazole-2-piperazine derivative shown in the general formula (I), a preparing method of the derivative, a pharmaceutical composition containing the derivative and application of the derivative serving as a therapeutic agent, especially serving as a poly (ADP-ribose) polymerase (PARP) inhibitor. In the general formula (I), R refers to hydrogen or halogen, G refers to carbonyl or methylene, m is 1-2, n is 1-3, and Q refers to hydrogen or C1-C4 alkyl. When X is methylene and Y is NR1 or methylene, X is NR1; R1 refers to hydrogen, C1-C6 alkyl, benzyl, COR2 or SO2R2; R2 refers to the following groups which are not substituted or groups substituted by 1-3 substituent groups, including C1-C6 alkyl, C3-C8 naphthenic base, phenyl, benzyl, naphthyl and C5-C10 aromatic heterocycle base, heterocycle in the C5-C10 aromatic heterocycle base comprises 1-3 heteroatoms selected from N, O and S, and the substituent groups are selected from the following atoms or groups of C1-C6 alkyl, C1-C6 alkoxy, halogen, amidogen, nitryl, sulfydryl, hydroxyl, cyanogroup and trifluoromethyl. The general formula (I) is shown in the specification.

L-Proline derived nitrogenous steroidal systems: An asymmetric approach to 14-azasteroids

An efficient chiral pool approach using l-proline to access 14-azasteroids under mild reaction conditions has been described. The key step involves the intramolecular SN2′ cyclization reaction for the construction of critical C-ring in the nitrogen impregnated steroidal architectures bearing unsaturation at Δ9(11) position. In the endeavour to synthesize some new congeners, the remote electronic impact of the electron donating groups in A ring and heteroatoms like oxygen in B ring, on the propensity of C-ring cyclization was also observed.

Synthesis of NP25302

An efficient synthesis of NP25302 is presented that relies on 5-endo-dig N-cyclization to establish the bicyclic core and Curtius rearrangement to install the N-acyl vinylogous urea functionality.