851050-45-8

Upstream product

• 851050-44-7 3-O-benzyl-5-O-(4,4'-dimethoxytrityl)-4-C-(4,4'-dimethoxytrityloxy)methyl-3-C-ethynyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 851050-39-0 3-C-ethynyl-4-C-(hydroxymethyl)-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 851050-37-8 5-O-(tert-butyldimethylsilyl)-4-C-(tert-butyldimethylsilyloxymethyl)-1,2-O-isopropylidene-β-L-threo-pentofuranos-3-ulose 
• 851050-36-7 5-O-(tert-butyldimethylsilyl)-4-C-(tert-butyldimethylsilyloxymethyl)-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 851050-35-6 3-O-benzyl-5-O-(tert-butyldimethylsilyl)-4-C-(tert-butyldimethylsilyloxymethyl)-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 851050-38-9 5-O-(tert-butyldimethylsilyl)-4-C-(tert-butyldimethylsilyloxymethyl)-1,2-O-isopropylidene-3-C-[2-(trimethylsilyl)ethynyl]-α-D-erythro-pentofuranose 
• 851050-74-3 5-O-(4,4'-dimethoxytrityl)-4-C-(4,4'-dimethoxytrityloxy)methyl-3-C-ethynyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 72261-44-0 1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 
• 22529-61-9 (1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol 
• 18685-18-2 3-O-benzyl-1,2-5,6-O-diisopropylidene-α-D-glucofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 
• 53167-11-6 1,2-O-isopropylidene-α-D-xylo-pentodialdo-1,4-furanose 
• 55797-64-3 1,2-O-isopropylidene-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 

Downstream Products

• 851050-75-4 3-O-benzyl-3-C-ethynyl-4-C-(methanesulfonyloxy)methyl-5-O-methanesulfonyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 851050-49-2 (1S,3R,4R,7S)-7-benzyloxy-7-ethynyl-1-(hydroxy)methyl-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 851050-46-9 1,2-di-O-acetyl-3-O-benzyl-3-C-ethynyl-4-C-(methanesulfonyloxy)methyl-5-O-methanesulfonyl-D-erythro-pentofuranose 
• 851050-48-1 (1R,3R,4R,7S)-7-benzyloxy-7-ethynyl-1-(methanesulfonyloxy)methyl-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 851050-77-6 Benzoic acid (1R,3R,4R,7S)-7-benzyloxy-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7-ethynyl-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 851050-47-0 1-[2-O-acetyl-3-O-benzyl-3-C-ethynyl-4-C-(methanesulfonyloxy)methyl-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl]uracil 

Relevant academic research and scientific papers

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3′-C- ethynylcytidine (ECYD)

A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3′-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer a

Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3′-C-ethynyluridine (EUrd) and 3′-C-ethynylcytidine (ECyd)

The synthesis of branched and conformationally restricted analogs of the anticancer nucleosides 3′-C-ethynyluridine (EUrd) and 3′-C- ethynylcytidine (ECyd) is presented. Molecular modeling and 1H NMR coupling constant analysis revealed that the furanose rings of all analogs except the LNA analog are conformationally biased towards South conformation, and are thus mimicking the structure of ECyd. All target nucleosides were devoid of anti-HIV or anticancer activity.